WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Complement and coagulation cascades       ID:04610
C=69; O=6; E=0.10; R=60.49; rawP=7.69e-10; adjP=7.69e-09
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000182326 NA C1S complement component 1, s subcomponent 716 ENSG00000182326
2  ENSG00000159403 NA C1R complement component 1, r subcomponent 715 ENSG00000159403
3  ENSG00000149131 NA SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 710 ENSG00000149131
4  ENSG00000000971 NA CFH complement factor H 3075 ENSG00000000971
5  ENSG00000112936 NA C7 complement component 7 730 ENSG00000112936
6  ENSG00000003436 NA TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 7035 ENSG00000003436


Database:KEGG pathway       Name:Systemic lupus erythematosus       ID:05322
C=136; O=4; E=0.20; R=20.46; rawP=4.58e-05; adjP=0.0002
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000182326 NA C1S complement component 1, s subcomponent 716 ENSG00000182326
2  ENSG00000159403 NA C1R complement component 1, r subcomponent 715 ENSG00000159403
3  ENSG00000112936 NA C7 complement component 7 730 ENSG00000112936
4  ENSG00000197903 NA HIST1H2BK histone cluster 1, H2bk 85236 ENSG00000197903


Database:KEGG pathway       Name:Staphylococcus aureus infection       ID:05150
C=55; O=3; E=0.08; R=37.94; rawP=7.04e-05; adjP=0.0002
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000182326 NA C1S complement component 1, s subcomponent 716 ENSG00000182326
2  ENSG00000159403 NA C1R complement component 1, r subcomponent 715 ENSG00000159403
3  ENSG00000000971 NA CFH complement factor H 3075 ENSG00000000971


Database:KEGG pathway       Name:Regulation of actin cytoskeleton       ID:04810
C=213; O=3; E=0.31; R=9.80; rawP=0.0036; adjP=0.0090
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000137809 NA ITGA11 integrin, alpha 11 22801 ENSG00000137809
2  ENSG00000112290 NA WASF1 WAS protein family, member 1 8936 ENSG00000112290
3  ENSG00000134853 NA PDGFRA platelet-derived growth factor receptor, alpha polypeptide 5156 ENSG00000134853


Database:KEGG pathway       Name:Lysosome       ID:04142
C=121; O=2; E=0.17; R=11.50; rawP=0.0132; adjP=0.0264
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000119655 NA NPC2 Niemann-Pick disease, type C2 10577 ENSG00000119655
2  ENSG00000177628 NA GBA glucosidase, beta, acid 2629 ENSG00000177628


Database:KEGG pathway       Name:Insulin signaling pathway       ID:04910
C=138; O=2; E=0.20; R=10.08; rawP=0.0170; adjP=0.0283
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000100504 NA PYGL phosphorylase, glycogen, liver 5836 ENSG00000100504
2  ENSG00000100889 NA PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 5106 ENSG00000100889


Database:KEGG pathway       Name:Metabolic pathways       ID:01100
C=1130; O=5; E=1.62; R=3.08; rawP=0.0232; adjP=0.0290
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000100889 NA PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 5106 ENSG00000100889
2  ENSG00000131446 NA MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 4245 ENSG00000131446
3  ENSG00000124212 NA PTGIS prostaglandin I2 (prostacyclin) synthase 5740 ENSG00000124212
4  ENSG00000138356 NA AOX1 aldehyde oxidase 1 316 ENSG00000138356
5  ENSG00000177628 NA GBA glucosidase, beta, acid 2629 ENSG00000177628


Database:KEGG pathway       Name:Jak-STAT signaling pathway       ID:04630
C=155; O=2; E=0.22; R=8.98; rawP=0.0211; adjP=0.0290
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000126561 NA STAT5A signal transducer and activator of transcription 5A 6776 ENSG00000126561
2  ENSG00000166888 NA STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 6778 ENSG00000166888


Database:KEGG pathway       Name:Focal adhesion       ID:04510
C=200; O=2; E=0.29; R=6.96; rawP=0.0337; adjP=0.0374
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000137809 NA ITGA11 integrin, alpha 11 22801 ENSG00000137809
2  ENSG00000134853 NA PDGFRA platelet-derived growth factor receptor, alpha polypeptide 5156 ENSG00000134853


Database:KEGG pathway       Name:Pathways in cancer       ID:05200
C=326; O=2; E=0.47; R=4.27; rawP=0.0801; adjP=0.0801
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000126561 NA STAT5A signal transducer and activator of transcription 5A 6776 ENSG00000126561
2  ENSG00000134853 NA PDGFRA platelet-derived growth factor receptor, alpha polypeptide 5156 ENSG00000134853




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).